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Showing posts from May, 2025

IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data Identification Product NameTRICYCLODECANEDIMETHANOL DIACRYLATEIUPAC Namedecanyl]methyl prop-2-enoate Molecular StructureCAS Registry Number 42594-17-2Synonymstricyclodecanedimethanol diacrylateDTXSID5044940EINECS 255-901-3A0HH0W4E4QDTXCID30249402-Propenoic acid, (octahydro-4,7-methano-1H-indene-5,?-diyl)bis(methylene) esterEC 255-901-3(Octahydro-4,7-methano-1H-indenediyl)bis(methylene) diacrylate2-Propenoic acid, (octahydro-4,7-methano-1H-indene-1,5(1,6 or 2,5)diyl)bis(methylene) ester2-Propenoic acid, 1,1'-((octahydro-4,7-methano-1H-indene-5,?-diyl)bis(methylene)) ester2-Propenoic acid, 1,1'- esterdimethyloldicyclopentane diacrylatedimethyloltricyclodecane diacrylateDicyclopentadienedimethanol diacrylateTRICYCLODECANEDIMETHANOL DIACRYLATE BIS(ACRYLOYLOXYMETHYL)TRICYCLO(5.2.1.02,6)DECANEBIS(HYDROXYMETHYL)TRICYCLO(5.2.1.02,6)DECANE DIACRYLATEdicyclopentyldimethylene diacrylatetricyclo(5.2.1.0...

IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data Identification Product Name2-CARBOXYETHYL ACRYLATEIUPAC Name3-prop-2-enoyloxypropanoic acidMolecular StructureCAS Registry Number 24615-84-7MDL NumberMFCD00040709Synonyms2-Carboxyethyl acrylate24615-84-72-Propenoic acid, 2-carboxyethyl esterHydracrylic acid, acrylatecarboxyethyl acrylate3-(Acryloyloxy)propionic acidKM1E1216WRDTXSID2027834ACRYLIC ACID DIMEREBECRYL .BETA.-CEAARONIX M 566C 800 (ACRYLATE)DTXCID807834ACRYLIC ACID 2-CARBOXYETHYL ESTER.BETA.-HYDROXYPROPIONIC ACID ACRYLIC ESTEREBECRYL BETA-CEACARBOXYETHYL ACRYLATE BETA-HYDROXYPROPIONIC ACID ACRYLIC ESTER246-359-93-prop-2-enoyloxypropanoic acid3-(acryloyloxy)propanoic acidbeta-Carboxyethyl acrylate2-Carboxyethyl 2-propenoate2-carboxyethylacrylateHydracrylic acid acrylateSipomer B-CEA3-Acryloyloxypropionic acidCAS-24615-84-7beta-(Acryloyloxy)propionic acidEINECS 246-359-9UNII-KM1E1216WRbeta-carboxyethylacrylatebeta carboxyethyl acrylatebeta-a...

IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data Identification Product NameLentinanIUPAC Name(2R,3R,4S,5S,6R)-2-oxy-6-oxymethyl]oxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5,6-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol Molecular StructureCAS Registry Number 37339-90-5SynonymsLENTINAN37339-90-5BromodulineBiomodulineLC-33UNII-6751655D1DDRG-0171SCHEMBL1517264DTXSID30190781MAXBMUKIXLNXGX-DMWITZOWSA-NAKOS040758705FL33321DA-548516751655D1DNS00123381E80771Molecular FormulaC42H72O36 Molecular Weight1153InChIInChI=1S/C42H72O36/c43-1-8-15(48)22(55)25(58)37(69-8)66-6-13-20(53)32(28(61)36(65)68-13)75-40-29(62)33(18(51)11(4-46)72-40)77-41-30(63)34(19(52)12(5-47)73-41)78-42-31(64)35(76-39-27(60)24(57)17(50)10(3-45)71-39)21(54)14(74-42)7-67-38-26(59)23(56)16(49)9(2-44)70-38/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22+,23+,24+,25-,26-,27-,28-,29-,30-,31-...

IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data Identification Product NameD-PHE-PIP-ARG-PNAIUPAC Name1--N-piperidine-2-carboxamideMolecular StructureCAS Registry Number 115388-96-0Synonyms115388-96-0D-Phe-L-pipecolyl-Arg-p-nitroanilide dihydrochloride634-224-0D-Phe-Pip-Arg-PNA1--N-piperidine-2-carboxamideH-D-Phe-Homopro-Arg-pNA.diacetateS-2238(Thrombin Substrate)DA-64083FP110749Molecular FormulaC27H36N8O5 Molecular Weight552.6InChIInChI=1S/C27H36N8O5/c28-21(17-18-7-2-1-3-8-18)26(38)34-16-5-4-10-23(34)25(37)33-22(9-6-15-31-27(29)30)24(36)32-19-11-13-20(14-12-19)35(39)40/h1-3,7-8,11-14,21-23H,4-6,9-10,15-17,28H2,(H,32,36)(H,33,37)(H4,29,30,31)/t21-,22+,23?/m1/s1InChI KeyYDMBNDUHUNWWRP-AXWGZAFASA-NCanonical SMILESC1CCN(C(C1)C(=O)N(CCCN=C(N)N)C(=O)NC2=CC=C(C=C2)(=O))C(=O)(CC3=CC=CC=C3)N Physical Data AppearanceOff-White to Pale Blue Solid Spectra No data available Route of Synthesis (ROS) No data available Safety and Hazards Pictogram(s)SignalWarnin...

以核心技术攻克司美格鲁肽侧链“卡脖子”环节，驱动GLP-1药物高效生产

Watson提供Fmoc-AEEA CAS 166108-71-0或者AEEA-AEEA CAS 1143516-05-5两种中间体选项，确保产品纯度达到99.0%，最大单一杂质不高于0.3%。Watson的Fmoc-Glu-OtBu CAS 84793-07-7或者不带保护的Glu-OtBu CAS 45120-30-7的光学纯度达到99.5%，同时确保最大单一杂质严格限定在不超过0.3%，甚至针对头部药企对杂质毒理研究的“零容忍”需求，更可在不大幅增加成本的前提下定制不超过0.1%的超严苛标准 https://www.youtube.com/watch?v=2R1nrIr-L_M

Overcoming the "Choke Points" in Semaglutide Side Chain Synthesis with Core Technologies to Enable Efficient GLP-1 Drug Manufacturing

Semaglutide, a groundbreaking product in the GLP-1 drug class, owes its extended half-life and enhanced receptor affinity largely to its unique side chain, Ste-Glu-AEEA-AEEA-OSU (CAS: 1169630-40-3) . This side chain covalently modifies the peptide backbone, significantly improving pharmacokinetics and therapeutic performance. However, its complex structure presents two critical synthetic challenges: Precise Assembly of Repetitive AEEA Units: The side chain features consecutive AEEA (aminoethoxyethoxyacetic acid) units, which require stepwise coupling via highly activated intermediates (e.g., AEEA-AEEA). Any impurities or deviations compromise downstream reaction efficiency and may trigger irreversible byproducts. Stereochemistry and Stability of Glutamic Acid (Glu): The glutamic acid component must maintain strict L-configuration, and its carboxyl groups require directional protection (e.g., OtBu) to preserve biological activity. Leveraging deep expertise in peptide chemistry a...

Overcoming the "Choke Points" in Semaglutide Side Chain Synthesis with Core Technologies

To address the diverse process requirements in semaglutide side chain synthesis, Watson offers two intermediate options: Fmoc-AEEA (CAS: 166108-71-0) and AEEA-AEEA (CAS: 1143516-05-5). And Watson's Fmoc-Glu-OtBu (CAS: 84793-07-7) and Glu-OtBu (CAS: 45120-30-7) products achieve 99% purity, 99.5% Optical Purity and 0.1% single impurities. https://www.youtube.com/watch?v=ft0YlbgBdDs

IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data Identification Product NamePOLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATEIUPAC Name2-methoxyethyl prop-2-enoate Molecular StructureCAS Registry Number 32171-39-4MDL NumberMFCD00803685Synonyms2-METHOXYETHYL ACRYLATE3121-61-7Methoxyethyl acrylate2-Propenoic acid, 2-methoxyethyl esterEthylene glycol methyl ether acrylateMethyl cellosolve acrylateEthylene glycol monomethyl ether acrylate2-Methoxyethanol, acrylateSipomer MCAAcrylic acid, 2-methoxyethyl esterGlycol monomethyl ether acrylateAcrylic acid, 2-methoxyethoxy esterEthanol, 2-methoxy-, acrylate2-Propenioc acid, 2-methoxyethyl esterNSC 24153Ageflex MEAEINECS 221-499-3BRN 1754333AI3-15726NSC-24153515K4I683YDTXSID7025554EC 221-499-3METHOXYETHYL ACRYLATE, 2-2-METHOXYETHYL 2-PROPENOATEDTXCID605554SR 244Acrylic acid, 2-methoxyethyl ester (8CI)221-499-32-methoxyethyl prop-2-enoate32171-39-42-Methoxyethoxy acrylateMFCD008036852-MethoxyethylacrylatemPEG-Acry...

IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data Identification Product NameL-(+)-SelenomethionineIUPAC Name(2S)-2-amino-4-methylselanylbutanoic acidMolecular StructureCAS Registry Number 3211-76-5MDL NumberMFCD00037210SynonymsL-selenomethionine3211-76-5Seleno-L-methionineSelenium-L-methionineL-SelenomethioninumSeMet(S)-2-Amino-4-(methylselanyl)butanoic acid(2S)-2-amino-4-methylselanylbutanoic acid(S)-2-Amino-4-(methylseleno)butyric acid(S)-2-Amino-4-(methylseleno)butanoic acid(2S)-2-amino-4-(methylseleno)butanoic acidL-(+)-SelenomethionineMFCD00037210Butyric acid, 2-amino-4-(methylselenyl)-, L-Butanoic acid, 2-amino-4-(methylseleno)-, (S)-NSC-760370964MRK2PELDTXSID8046824CHEBI:30021NCGC00181044-01Selenomethionine MSE(2s)-2-amino-4-(methylselanyl)butanoic acidSelenoSource AF 2000C5H11NO2SeUNII-964MRK2PELButanoic acid, 2-amino-4-(methylseleno)-, (2S)-(2S)-2-amino-4-methylselanyl-butanoic acidMegavite RXSeleno-DL-methionine;DL-Selenomethionine(2S)-2...

IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data Identification Product Nameisotridecan-1-olIUPAC Name11-methyldodecan-1-ol Molecular StructureCAS Registry Number 27458-92-0EINECS Number288-581-9MDL NumberMFCD00044077SynonymsIsotridecanol11-MethyldodecanolISOTRIDECYL ALCOHOL11-methyldodecan-1-olIsotridecan-1-ol85763-57-111-Methyl-1-dodecanolIsotridecanol-UNII-VX3T72M5SGEINECS 248-469-2VX3T72M5SGEINECS 288-581-9DTXSID7058676CHEBI:77438EC 248-469-2DTXCID208687DTXSID1029752ISOTRIDECYL ALCOHOL 288-581-9xujlwpfsuchpql-uhfffaoysa-nIso-Tridecyl-alcohol27458-92-011-Methyl-1-dodecanol;1-Dodecanol, 11-methyl-FIXATEUR ITCEINECS 271-235-6EC 271-235-6SCHEMBL22209AKOS028108421FM25817DB-255063DB-255064DB-259336NS00006896F70509Q27146966Molecular FormulaC13H28OMolecular Weight200.36InChIInChI=1S/C13H28O/c1-13(2)11-9-7-5-3-4-6-8-10-12-14/h13-14H,3-12H2,1-2H3InChI KeyXUJLWPFSUCHPQL-UHFFFAOYSA-N SMILESCC(C)CCCCCCCCCCO Physical Data AppearanceColorless clear liquid S...

ChemWhat Channel: Chemistry and Biology Insights

ChemWhat即"凯望"的PEG连接子产品已广泛供应给北美、欧洲、日本、韩国及中国等国家和地区的多家头部生物医药企业，并多次被选为战略供应商。合作范围涵盖早期药物筛选、小试放大至GMP级原料供应，体现出客户对其质量控制体系、交付效率与技术支持能力的高度认可。多个全球药企与Watson建立了长期合作关系，这也彰显了Watson在连接子材料领域的综合竞争力与可持续服务能力。 https://www.youtube.com/watch?v=Uh9fOWa8NIM

Watson International: A Global Leader in High-Purity PEG Linkers for Antibody-Drug Conjugate (ADC) Innovation

As the industry continues to pursue more stable, effective, and targeted treatments, Watson International, the brand owner of ChemWhat®, has earned global recognition as a trusted manufacturer of high-purity polyethylene glycol (PEG) linkers—tailor-made to accelerate antibody-drug conjugates (ADC) development and commercialization.

Watson International: A Global Leader in High-Purity PEG Linkers for Antibody-Drug Conjugate (ADC) Innovation

In the realm of modern biopharmaceutical innovation, antibody-drug conjugates (ADCs) represent a promising frontier—one that combines the specificity of monoclonal antibodies with the potency of cytotoxic agents. At the core of this technology lies a critical component: the linker, which bridges the antibody and the drug payload. Among the various types of linkers, polyethylene glycol (PEG) linkers have gained widespread prominence due to their unique physicochemical properties and ability to improve the pharmacokinetic profile of therapeutics. As the industry continues to pursue more stable, effective, and targeted treatments, Watson International, the brand owner of ChemWhat®, has earned global recognition as a trusted manufacturer of high-purity PEG linkers—tailor-made to accelerate ADC development and commercialization. The Role of PEG Linkers in ADCs Polyethylene glycol (PEG) linkers serve several vital functions in the design of antibody-drug conjugates: Improved Solubility...

Watson - A Global Leader in High-Purity PEG Linkers for Antibody-Drug Conjugate (ADC) Innovation

In the fast-evolving landscape of targeted cancer therapies, polyethylene glycol (PEG) linkers play a pivotal role in the design and efficacy of antibody-drug conjugates (ADCs). Among the many suppliers in this competitive field, Watson, the brand owner of ChemWhat®, has emerged as a globally recognized leader, renowned for its high-purity PEG linkers that meet the rigorous demands of advanced pharmaceutical research and development. https://www.youtube.com/watch?v=CV3kAvGecSg