Overcoming the "Choke Points" in Semaglutide Side Chain Synthesis with Core Technologies to Enable Efficient GLP-1 Drug Manufacturing

IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data

Identification

Product Name3-AtetrakistetramethylcyclotetrasiloxaneIUPAC Name2,4,6,8-tetramethyl-2,4,6,8-tetrakisheptan-3-yl)ethyl]-1,3,5,7,2,4,6,8-tetraoxatetrasilocaneMolecular StructureCAS Registry Number 121225-98-7Synonyms3-Pyridinamin;3-Pyridinamine;3-Pyridinamine;pyridin-3-amine;T6NJ CZ;3- Aminopyridine;3-Amino-pyridine;3-pyridylamine;Amino-3 pyridine;m-Aminopyridine;MS/MS-1064463;Pyridin-3-ylamine;Pyridine, 3-amino-;β-Aminopyridine462-08-8Molecular FormulaC5H6N2Molecular Weight94.116InChIInChI=1S/C5H6N2/c6-5-2-1-3-7-4-5/h1-4H,6H2InChI KeyCUYKNJBYIJFRCU-UHFFFAOYSA-NCanonical SMILESC1=CC(=CN=C1)N

Physical Data

AppearanceColorless to light yellow transparent liquid

Spectra

Description (NMR Spectroscopy)Nucleus (NMR Spectroscopy)Solvents (NMR Spectroscopy)Chemical shifts, Spectrum1Hchloroform-d1

Description (IR Spectroscopy)Spectrum

Route of Synthesis (ROS)

Route of Synthesis (ROS) of PHOSPHOENOLPYRUVIC ACID MONOPOTASSIUM SALT CAS 4265-07-0

ConditionsYield2C8H18S3Cl(1-)Rh(3+) In ethanol; hexane at 95 - 128.5℃; for 4.5h; Heating / reflux;platinum(II)Cl2(bis(triphenylphsphine)) In dichloromethane; toluene at 123 - 135℃; for 3h; Heating / reflux;Experimental Procedure2 Example 2.This example describes the preparation of 1,3,5,7-tetrakis(1,2-epoxy-4-cyclohexylethyl)-1,3,5,7-tetramethylcyclotetra-siloxane, DE4, (represented by formula (III)) using parts per billion levels of PtCl2(PPh3)2 as the hydrosilation catalyst. A 1-liter, 3-necked round-bottomed flask equipped with two condensers and a thermometer was charged with VCHO (122 g. 981 mmol).. 49 g (204 mmol) DH4 (1,3,5,7-tetramethylcyclotetrasiloxane), 4 microliters of PtCl2(PPh3)2 catalyst solution (140 ppb Pt based on final product weight) and 83 g toluene.. The reaction solution was heated to reflux with stirring, resulting in a solution temperature of 123°C. At this point the reaction mixture began to reflux vigorously, with the solution temperature reaching 135°C initially, and thereafter settling down at 130°C. The mixture was then refluxed for about 3 hours.. At this point, the infrared spectrum of an aliquot of the reaction mixture showed no Si-H absorption indicating complete consumption of DH4The solution was cooled to room temperature, and the condensers and thermometer were replaced with stopcocks and a short-path distillation head.. The solution was heated with a water bath at 85°C and stripped of volatile components until the vapor temperature was above 70°C. No gel formation was observed during and after the stripping process.. Proton NMR spectrum of the residual material in the reaction flask showed it to be the desired product and free of residual solvent and VCHO. In this manner, 148 g of (III) was obtained as a colorless material.With potassium chloroplatinate In toluene at 70℃; for 24h;75 %Spectr.

Safety and Hazards

Pictogram(s)SignalWarningGHS Hazard StatementsH319 (100%): Causes serious eye irritation Precautionary Statement CodesP264+P265, P280, P305+P351+P338, and P337+P317(The corresponding statement to each P-code can be found at the GHS Classification page.)

Other Data

TransportationUnder room temperature away from lightHS CodeStorageUnder room temperature away from lightShelf LifeMarket Price

DruglikenessLipinski rules componentMolecular Weight737.241logP8.812HBA8HBD0Matching Lipinski Rules2Veber rules componentPolar Surface Area (PSA)87.04Rotatable Bond (RotB)12Matching Veber Rules1

Use PatternTetraepoxycyclohexylethyl 2,4,6,8-tetramethylcyclotetrasiloxane (TCECHTQ) has many advantages in LED packaging, adhesives and 3D printing due to its unique chemical properties and performance. LED Encapsulation: TCECHTQ exhibits excellent transparency, effectively enhancing the optical performance of LED encapsulation materials, ensuring efficient light transmission and reducing light loss. LEDs generate high temperatures during operation. TCECHTQ's high temperature resistance ensures stability of encapsulation materials under heat, preventing yellowing or decomposition. TCECHTQ can withstand UV radiation and other environmental factors, extending the lifespan of LED encapsulation and maintaining optical performance over time.Adhesives: Its chemical stability allows it to maintain bonding performance across various environments, resistant to chemical agents and environmental changes. TCECHTQ's elasticity and flexibility enable it to adhere well to diverse materials and surfaces, expanding the applicability and durability of adhesives.3D Printing: TCECHTQ possesses good flowability and curing properties, enabling high-precision printing suitable for complex structures and detailed requirements in 3D printing models. Its fast curing characteristics improve 3D printing efficiency, reducing printing time and enhancing production efficiency.Improved light efficiency and lifespan in LED encapsulation; increased bonding strength and durability in adhesives; achieving high precision and efficiency in 3D printing. Outstanding weather resistance and chemical stability ensure long-term performance stability in various environments, prolonging product lifespan.
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