IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data
Identification
Product NameDextranIUPAC Name2,3,4,5-tetrahydroxy-6-oxymethyl]oxan-2-yl]oxyhexanalMolecular StructureCAS Registry Number 9004-54-0EINECS Number232-677-5MDL NumberMFCD00132771SynonymsDEXTRAN9004-54-0Dextran 40Macrodex2,3,4,5-tetrahydroxy-6-oxymethyl]oxan-2-yl]oxyhexanalHexopyranosyl-(1->6)hexopyranosyl-(1->6)hexoseDextran 706-O-(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)-D-glucose13382-86-0MediumDextran T40Dextran-500kdSEPHADEX G-50Dextran (MW 70000)Dextran (Mw 150000)SCHEMBL12557981DTXSID00864149FZWBNHMXJMCXLU-UHFFFAOYSA-N(2R,3S,4R,5R)-2,3,4,5-tetrahydroxy-6-oxymethyl]oxan-2-yl]oxyhexanalBCP13568AKOS015915689D1448D1449DEX 500; Detrax 40; Dextranen; DextravenG726252,3,4,5-tetrahydroxy-6-((3,4,5-trihydroxy-6-(((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)hexanalMolecular FormulaC18H32O16Molecular Weight504.4InChIInChI=1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2InChI KeyFZWBNHMXJMCXLU-UHFFFAOYSA-NIsomeric SMILESC(C1C(C(C(C(O1)OCC2C(C(C(C(O2)OCC(C(C(C(C=O)O)O)O)O)O)O)O)O)O)O)O
Patent InformationPatent IDTitlePublication DateUS5104787Method for apparatus for a defined serumfree medical solution useful for corneal preservation1992EP516901Method and apparatus of a serumfree medical solution1992US2009/47336NOVEL FORMULATION OF DEHYDRATED LIPID VESICLES FOR CONTROLLED RELEASE OF ACTIVE PHARMACEUTICAL INGREDIENT VIA INHALATION2009US2012/148542MACHINE PERFUSION WITH COMPLEMENT INHIBITORS2012US5849884Macromolecular microparticles and methods of production and use1998
Physical Data
AppearanceWhite or light yellow delicate powder
Description (Association (MCS))Solvent (Association (MCS))Temperature (Association (MCS)), °CPartner (Association (MCS))Adsorption isothermvarious solvent(s), H2O204-Fluozeolite YFurther physical properties of the complexAzinc tetrakis(4-carboxyphenyl)porphyrinUV/VIS spectrum of the complexH2O25Association with compoundH2O10 - 80bovine serum γ-globulin
Spectra
Description (NMR Spectroscopy)Nucleus (NMR Spectroscopy)Solvents (NMR Spectroscopy)Temperature (NMR Spectroscopy), °C Frequency (NMR Spectroscopy), MHzSpectrum1HSpectrum1Hwater-d2Chemical shifts, Spectrum1Hdimethylsulfoxide-d620Chemical shifts1Hdimethylsulfoxide-d6Spectrum13CChemical shifts, Spectrum1Hwater-d2Spectrum1H600
Description (IR Spectroscopy)Solvent (IR Spectroscopy)Bands, SpectrumIntensity of IR bands, ATR (attenuated total reflectance), Bands, SpectrumSpectrumBands, Spectrumpotassium bromide
Description (UV/VIS Spectroscopy)SpectrumAbsorption maxima
Route of Synthesis (ROS)
Route of Synthesis (ROS) of Dextran CAS# 9004-54-0
ConditionsYieldWith dicyclohexyl-carbodiimide In dimethyl sulfoxide for 24h; Heating / reflux;Experimental ProcedureEXAMPLE 8; Synthesis of Dextran 7OK Mono-carbonyl butanoic acid curcumin conjugate 2; Dextran 122 mg (3 x 10"3 mmol), Mono-carbonyl butanoic acid curcumin 16 mg (3Jx IO"4 mmol) and DCC (1, 3- dicyclohexylcarbodiimide) 10 mg (4.8χ lθ"4 mmol) were dissolved in 5.5 ml dry DMSO. The reaction was stirred for 24 h at reflux under argon The solution was filtered, dialyzed with SnakeSkin pleated dialysis tubing with Millipore water, centrifuged and lyophilized. The product resembled cotton candy and the yield was quantitative. NMR 1H (D2O), δ (ppm): compound 2,1.35-1.39 (m); 1.67 (m,); 1.78- 1.92 (bm); 2.33 (bm); 2.41-2.44 (t); 3.53-3.56 (t); 3.59-3.61 (m); 3.73-3.79 (m); 3.93- 4.02 (dd); 5.00 (d). Number of Curcumin molecules attached per polymer molecule is 22 (Estimated from UV spectroscopy using the extinction coefficient for Curcumin-COOH).100%
Safety and Hazards
GHS Hazard StatementsNot Classified
Other Data
TransportationUnder the room temperature and away from lightHS CodeStorageUnder the room temperature and away from lightShelf Life1 yearMarket Price
Use PatternDextran CAS#: 9004-54-0 commonly used for oil, paper and textile industries, such as photographic emulsion.
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