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Lemairamin CAS#: 29946-61-0
IdentificationPhysical DataSpectraRoute of Synthesis (ROS)Safety and HazardsOther Data

Identification

Product NameLemairaminMolecular StructureCAS Registry Number 29946-61-0MDL NumberMFCD00610628Synonyms2-Propenamide, N--3-phenyl-, (2E)-;Lemairamin (WGX-50)Molecular FormulaC19H21NO3Molecular Weight311.37

Physical Data

AppearanceWhite powder

Melting Point, °C Solvent (Melting Point) 124 - 126132124.5 - 126acetone119 - 120toluene122 - 124acetone, hexane127aq. ethanol

Spectra

Description (NMR Spectroscopy)Nucleus (NMR Spectroscopy)Solvents (NMR Spectroscopy)Temperature (NMR Spectroscopy), °C Frequency (NMR Spectroscopy), MHzChemical shifts1Hchloroform-d1500Chemical shifts13Cchloroform-d1125Chemical shifts1Hdimethylsulfoxide-d6300Chemical shifts, Spectrum1Hchloroform-d1300Chemical shifts, Spectrum13Cchloroform-d124.84125

Description (IR Spectroscopy)Solvent (IR Spectroscopy)Bandsneat (no solvent, solid phase)BandsKBr

Description (UV/VIS Spectroscopy)Solvent (UV/VIS Spectroscopy)Comment (UV/VIS Spectroscopy)Absorption Maxima (UV/VIS), nmExt./Abs. Coefficient, l·mol-1cm-1Absorption maximamethanol206, 277

Route of Synthesis (ROS)

Route of Synthesis (ROS) of Lemairamin CAS 29946-61-0

ConditionsYieldWith sodium hydroxide In dichloromethane at 20℃; for 3h; Schotten-Baumann Reaction;91%With sodium hydroxide In dichloromethane; water at 20℃; for 3h; Schotten-Baumann Reaction;91%Experimental Procedure An amount of 458mg of cinnamoyl chloride (2.76mmol) dissolved in CH2Cl2 (1mL) was added dropwise at 0°C to a solution of 2-(3,4-dimethoxyphenyl)ethylamine (500mg, 2.76mmol) in CH2Cl2 (20mL) and 5% aqueous NaOH (4.4mL) with stirring at room temperature for 3h. Then, the mixture was stirred with 2.5% aqueous HCl. The organic solution was washed with brine (2×10ml) and H2O (2×10ml), dried over anhydrous Na2SO4 and evaporated to dryness. The residue obtained was purified by silica gel column chromatography (Hexane/CH2Cl2/EtOAc, 20:70:10) to afford the acetamide 1 (781mg, 91%) as a white oil. 1H NMR (500MHz, CDCl3): δ=7.62 (d, J=15.6Hz, 1H, CH-β).

Safety and Hazards

No data available

Other Data

TransportationUnder room temperature and away from lightHS CodeStorageUnder the room temperature and away from lightShelf Life2 yearsMarket Price

Toxicity/Safety PharmacologyQuantitative Results

Use PatternLemairamin CAS#: 29946-61-0 used as the next generation of anti-aging material. And Lemairamin has some applications in the medical field, primarily due to its effects on the nervous system.
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